Lab overview

Bioex is linked to the Graduate Program in Health Sciences (PPGCS) of the School of Medicine at the Pontifical Catholic University of Paraná (PUCPR) in Brazil. Our research aims to understand the biochemical and molecular mechanisms induced by physical exercise on the redox biology in diverse tissues and organs. We use advanced technologies and research techniques to explore and investigate the scientific hypotheses formulated in our Laboratory. Our research is supported by government funding and other foundations.

OUR TEAM

The Bioex team is composed of researchers, undergraduate and postgraduate students (master's and doctorate), post-doc and collaborators. Know more about the members of our 2022 team below.

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Head of Lab and main investigator

Ricardo A. Pinho, PhD

Dr. Pinho has an undergraduate and a Master's degree in Physical Education (UFSC, Brazil,1992/1999) and a Ph.D. in Biological Sciences - Biochemistry (UFRGS, Brazil, 2005). Senior postdoctorate at the Muscle Health Research Centre - YU - Toronto. Dr. Pinho was the Director of Community Affairs, Coordinator for Graduate Studies and Research in Health Science, and Pro-rector for Graduate Studies and Research at Universidade do Extremo Sul Catarinense. Currently, Dr. Pinho is a professor of Graduate and undergraduate programs at the School of Medicine at Pontificia Universidade Católica do Paraná (PUCPR), Brazil. In the Graduate Program in Health Sciences, Dr. Pinho is a professor and supervisor (MSc and Ph.D.), honorary professor at Ningbo University, China, and Head of the Biochemistry of Exercise Lab in Health. He is a member of the Society for Free Radical Research - Europe and a Member of the Advisory Board in the Area of Biological Sciences of the Araucária Foundation (Paraná, Brazil). Acts as a reviewer for several international journals, he is an Associate Editor of The Annals of the Brazilian Academy of Science and Guest Editor of Antioxindats and Frontiers in Physiology. Dr. Pinho has experience in the Biochemistry and physiology of exercise, mainly oxidative stress and pathophysiology of chronic degenerative diseases. (CNPQ scientist , index-h = 36 Scopus, 49 Google Scholar).

Orcid: http://orcid.org/0000-0003-3116-4553

CV:  http://lattes.cnpq.br/0941343786335040

PROJECTS IN PROGRESS

Our projects aim to investigate the role of physical exercise and antioxidants on the redox response of degenerative diseases. Research in the  BIOEX involves a constant review of the scientific issues on exercise and health.The strength of our research lies in the breadth and depth of the experimental approaches we use in understanding the molecular and biochemical mechanisms induced by physical exercise. Learn more about our current research projects below.

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Exercise-induced neuroprotection in animals with Glioblastoma experimental

RECENT PUBLICATIONS

The results of our research are published in different international journals, which have been cited and recognized by other researchers. See some of our recent publications (2021/2022). You can find a complete list of our publications at Orcid:http://orcid.org/0000-0003-3116-4553

Susceptibility of the patients infected with Sars-Cov2 to oxidative stress and possible interplay with severity of the disease

Free Radic Biol Med. 2021 Mar;165:184-190.

https://pubmed.ncbi.nlm.nih.gov/33524532

Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model

An Acad Bras Cienc. 2021 May 31;93(2):e20191450.

https://pubmed.ncbi.nlm.nih.gov/

Effects of Zingiber officinale extract supplementation on metabolic and genotoxic parameters in diet-induced obesity in mice

Br J Nutr. 2021 Oct 14;126(7):970-981.

https://pubmed.ncbi.nlm.nih.gov/33323139/

The Dose Response of Taurine on Aerobic and Strength Exercises: A Systematic Review

Front Physiol. 2021 Aug 18;12:700352. 

https://pubmed.ncbi.nlm.nih.gov/34497536/

Bone-Marrow Stem Cells and Acellular Human Amniotic Membrane in a Rat Model of Heart Failure

Life (Basel). 2021 Sep 13;11(9):958.

https://pubmed.ncbi.nlm.nih.gov/34575107/

Distinct mechanisms involving diacylglycerol, ceramides, and inflammation underlie insulin resistance in oxidative and glycolytic muscles from high fat-fed rats

Sci Rep. 2021 Sep 27;11(1):19160. 

https://pubmed.ncbi.nlm.nih.gov/34580412/

Role of mononuclear stem cells and decellularized amniotic membrane in the treatment of skin wounds in rats

Tissue Barriers. 2022 Apr 3;10(2):1982364.

https://pubmed.ncbi.nlm.nih.gov/34612164/

Exercise Cuts Both Ways with ROS in Remodifying Innate and Adaptive Responses: Rewiring the Redox Mechanism of the Immune System during Exercise

Antioxidants (Basel). 2021 Nov 21;10(11):1846.

https://pubmed.ncbi.nlm.nih.gov/34829717/

Effects of the intranasal application of gold nanoparticles on the pulmonary tissue after acute exposure to industrial cigarette smoke

J Biomed Mater Res B Appl Biomater. 2022 Jun;110(6):1234-1244. 

https://pubmed.ncbi.nlm.nih.gov/34894049/

Modulatory Effects of Physical Activity Levels on Immune Responses and General Clinical Functions in Adult Patients with Mild to Moderate SARS-CoV-2 Infections-A Protocol for an Observational Prospective Follow-Up Investigation: Fit-COVID-19 Study

Int J Environ Res Public Health. 2021 Dec 16;18(24):13249.

https://pubmed.ncbi.nlm.nih.gov/34948858/

Exercise Cuts Both Ways with ROS in Remodifying Innate and Adaptive Responses: Rewiring the Redox Mechanism of the Immune System during Exercise

Antioxidants (Basel). 2021 Nov 21;10(11):1846.

https://pubmed.ncbi.nlm.nih.gov/34829717/

Effects of the intranasal application of gold nanoparticles on the pulmonary tissue after acute exposure to industrial cigarette smoke

J Biomed Mater Res B Appl Biomater. 2022 Jun;110(6):1234-1244. 

https://pubmed.ncbi.nlm.nih.gov/34894049/

Modulatory Effects of Physical Activity Levels on Immune Responses and General Clinical Functions in Adult Patients with Mild to Moderate SARS-CoV-2 Infections-A Protocol for an Observational Prospective Follow-Up Investigation: Fit-COVID-19 Study

Int J Environ Res Public Health. 2021 Dec 16;18(24):13249.

https://pubmed.ncbi.nlm.nih.gov/34948858/

Role of Body Mass and Physical Activity in Autonomic Function Modulation on Post-COVID-19 Condition: An Observational Subanalysis of Fit-COVID Study

Int J Environ Res Public Health. 2022 Feb 21;19(4):2457.

https://pubmed.ncbi.nlm.nih.gov/35206647/

Front Nutr. 2021 Dec 10;8:784429.

https://pubmed.ncbi.nlm.nih.gov/34957187/

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Lab Symposium

Symposium of Exercise Biochemistry in Health

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The Symposium of Exercise Biochemistry in Health is an event promoted by Bioex to disseminate scientific advances related to physical exercise's biochemical and molecular effects on human health. The event is held annually at PUCPR and has the participation of important researchers. In 2021 the event was held online on the 23rd, 24th, and 25th of June. The next event will be 2023

Website: https://bioex.pucpr.br

A little of our scientific and social routine

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Contact us

Thank you for your interest in our research. Please contact us if you have any questions or comments about our work and publications, or, if you wish to try out for a master´s degree, doctorate or a post-doc position. We would love to hear from you.

Adress: R. Imac. Conceição, 1155 - Prado Velho, Curitiba - PR, 80215-901, Brazil

Phone: (+55 48) 32716333

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