Laboratory of Exercise Biochemistry in Health
Ricardo Pinho´s Lab
Lab overview
Bioex is linked to the Graduate Program in Health Sciences (PPGCS) of the School of Medicine at the Pontifical Catholic University of Paraná (PUCPR) in Brazil. Our research aims to understand the biochemical and molecular mechanisms induced by physical exercise on the redox biology in diverse tissues and organs. We use advanced technologies and research techniques to explore and investigate the scientific hypotheses formulated in our Laboratory. Our research is supported by government funding and other foundations.
OUR TEAM
The Bioex team is composed of researchers, undergraduate and postgraduate students (master's and doctorate), post-doc and collaborators. Know more about the members of our 2025 team below.
Head of Lab and main investigator
Ricardo A. Pinho, PhD
Dr. Pinho has an undergraduate and a Master's degree in Physical Education (UFSC, Brazil,1992/1999) and a Ph.D. in Biological Sciences - Biochemistry (UFRGS, Brazil, 2005). Dr. Pinho is a professor of Graduate and undergraduate programs at the School of Medicine and Life Sciences at Pontificia Universidade Católica do Paraná (PUCPR), Brazil. In the Graduate Program in Health Sciences, Dr. Pinho is a professor and supervisor (MSc and Ph.D.), honorary professor at Ningbo University, China, and Head of the Biochemistry of Exercise Lab in Health. He is a member of the Society for Free Radical Research - Europe and a Member of the Advisory Board in the Area of Biological Sciences of the Araucária Foundation (Paraná, Brazil). Acts as a reviewer for several international journals and an Associate Editor. Dr. Pinho has experience in the Biochemistry and physiology of exercise, mainly oxidative stress and pathophysiology of chronic degenerative diseases. (CNPQ scientist , index-h = 402).
PROJECTS IN PROGRESS
Research in the BIOEX involves a constant review of the scientific issues on exercise and health. The strength of our research lies in the breadth and depth of the experimental approaches we use in understanding the molecular and biochemical mechanisms induced by physical exercise. Learn more about our current research projects below.
The role of the Sodium-glucose cotransporter 2 (SGLT2) inhibitor and physical exercise in the regulation of the redox system and the inflammassoma complex in animals with obesity and experimental diabetic nephropathy
RECENT PUBLICATIONS
The results of our research are published in different international journals, which have been cited and recognized by other researchers. See some of our recent publications (2024/2025). You can find a complete list of our publications at Orcid:http://orcid.org/0000-0003-3116-4553
2025
Machado-Junior, Paulo Andre Bispo, Andre Lass, Julia de Bortolo, Leticia Bressan Anizelli, Mateus T. Rocha, Henrique Machado Sousa Proença, Stephanie Rubianne Silva Carvalhal, et al. 2025. “Sodium-Glucose Cotransporter-2 Inhibitor Improves Renal Injury by Regulating the Redox Profile, Inflammatory Parameters, and Pyroptosis in an Experimental Model of Diabetic Kidney Disease.” ACS Pharmacology &Amp; Translational Science, April. https://doi.org/10.1021/acsptsci.4c00552.
Zhou, Lei, Soroosh Mozaffaritabar, Erika Koltai, Smaragda Giannopoulou, Attila Kolonics, Yaodong Gu, Ricardo A. Pinho, Ildiko Miklossy, Istvan Boldogh, and Zsolt Radák. 2025. “Consecutive Skeletal Muscle PGC-1 Overexpression: A Double-Edged Sword for αMitochondrial Health in the Aging Brain.” Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease 1871 (6): 167851. https://doi.org/10.1016/j.bbadis.2025.167851.
Farkas, Gabor, Zahira El Mahdaouy, Gergely Babszky, Matyas Jokai, Ferenc Torma, Yaodong Gu, Ricardo Pinho, et al. 2025. “Associations of Epigenetic Aging and COVID- 19: A 3-Year Longitudinal Study.” GeroScience, April. https://doi.org/10.1007/s11357-025-01635-4.
Deus, Marina de Castro, Ana Carolina Gadotti, Erika Sousa Dias, Júlia Bacarin Monte Alegre, Beatriz Akemi Kondo Van Spitzenbergen, Gabriela Bohnen Andrade, Sara Soares Tozoni, et al. 2024. “Prospective Variation of Cytokine Trends During COVID-19: A Progressive Approach from Disease Onset Until Outcome.” International Journal of Molecular Sciences 25 (19): 10578. https://doi.org/10.3390/ijms251910578.
Cavalcante GV, Fedato R, de Noronha L, Nagashima S, Martins APC, Olandoski M, Pinho R, Takejima A, Simeoni R, Francisco JC, Guarita-Souza LC. Histological Alterations and Interferon-Gamma and AKT-mTOR Expression in an Experimental Model of Achilles Tendinopathy-A Comparison of Stem Cell and Amniotic Membrane Treatment. Biomedicines. 2025 Feb 19;13(2):525. doi: 10.3390/biomedicines13020525.
2024
Lei, Zhou, Soroosh Mozaffaritabar, Takuji Kawamura, Atsuko Koike, Attila Kolonics, Johanna Kéringer, Ricardo A. Pinho, Jingquan Sun, Ruonan Shangguan, and Zsolt Radák. 2024. “The Effects of Long-Term Lactate and High-Intensity Interval Training (HIIT) on Brain Neuroplasticity of Aged Mice.” Heliyon 10 (2): e24421. https://doi.org/10.1016/j.heliyon.2024.e24421.
Machado Júnior, Paulo André Bispo, André Lass, Bruna Isadora Pilger, Raphaella Fornazari, Thyago Proença de Moraes, and Ricardo Aurino Pinho. 2024. “SGLT2 Inhibitors and NLRP3 Inflammasome: Potential Target in Diabetic Kidney Disease.” Brazilian Journal of Nephrology 46 (4). https://doi.org/10.1590/2175-8239-jbn-2023-0187en.
Pilger, Bruna I., Alex Castro, Franciane F. Vasconcellos, Karen F. Moura, Étore De Favari Signini, Luis Felipe B. Marqueze, Edson A. FiorenzaNeto, et al. 2024. “Obesitydependent ‐‐Molecular Alterations in Fatal COVID19: A Retrospective Postmortem Study of ‐Metabolomic Profile of Adipose Tissue.” Journal of Cellular Biochemistry 125 (6). https://doi.org/10.1002/jcb.30566.
Pinho, R. A., A. P. Muller, L. F. Marqueze, Z. Radak, and R. M. Arida. 2024. “Physical Exercise-Mediated Neuroprotective Mechanisms in Parkinson’s Disease, Alzheimer’s Disease, and Epilepsy.” Brazilian Journal of Medical and Biological Research 57. https://doi.org/10.1590/1414-431x2024e14094.
Radak, Zsolt, Lang Pan, Lei Zhou, Soroosh Mozaffaritabar, Yaodong Gu, Ricardo A. Pinho, Xu Zheng, Xueqing Ba, and Istvan Boldogh. 2024. “Epigenetic and ‘Redoxogenetic’ Adaptation
to Physical Exercise.” Free Radical Biology and Medicine 210 (January): 65–74. https://doi.org/10.1016/j.freeradbiomed.2023.11.005.
Takejima, aline l., Paulo André B. Machado-júnior, Gustavo G. Blume, Rossana Baggio Simeoni, Julio Cesar Francisco, Murilo S. Tonial, Luis Felipe B. Marqueze, Ricardo. A Pinho, Luiz Cesar Guartia et al. 2024. “Bone-Marrow Mononuclear Cells and Acellular Human Amniotic Membrane Improve Global Cardiac Function Without Inhibition of the NLRP3 Inflammasome in a Rat Model of Heart Failure.” Anais Da Academia Brasileira de Ciências 96 (1). https://doi.org/10.1590/0001-3765202420230053.
Thirupathi, Anand, Luis Felipe Marqueze, Tiago F. Outeiro, Zsolt Radak, and Ricardo A. Pinho. 2024. “Physical Exercise-Induced Activation of NRF2 and BDNF as a Promising Strategy for Ferroptosis Regulation in Parkinson’s Disease.” Neurochemical Research 49 (7): 1643–54. https://doi.org/10.1007/s11064-024-04152-6.
da Silva LA, Boeira D, Doeynart R, Longen WC, Marqueze LF, Silveira PCL, Thirupathi A, Gu Y, Pinho RA. Effects of aerobic exercise during recovery from eccentric contraction on muscular performance, oxidative stress and inflammation. Curr Res Physiol. 2024 Jun 15;7:100129. doi: 10.1016/j.crphys.2024.100129.
Deus MC, Gadotti AC, Dias ES, Monte Alegre JB, Van Spitzenbergen BAK, Andrade GB, Tozoni SS, Stocco RB, Olandoski M, Tuon FFB, Pinho RA, de Noronha L, Baena CP, Moreno-Amaral AN. Prospective Variation of Cytokine Trends during COVID-19: A Progressive Approach from Disease Onset until Outcome. Int J Mol Sci. 2024 Oct 1;25(19):10578. doi: 10.3390/ijms251910578
Lab Symposium
Symposium of Exercise Biochemistry in Health
The Symposium of Exercise Biochemistry in Health is an event promoted by Bioex to disseminate scientific advances related to physical exercise's biochemical and molecular effects on human health. The event is held annually at PUCPR and has the participation of important researchers. The next event will be November 2026 .
A little of our scientific and social routine
©2019 by Laboratory of Exercise Biochemistry in Health. Proudly created with Wix.com
Contact us
Thank you for your interest in our research. Please contact us if you have any questions or comments about our work and publications, or, if you wish to try out for a master´s degree, doctorate or a post-doc position. We would love to hear from you.
Adress: R. Imac. Conceição, 1155 - Prado Velho, Curitiba - PR, 80215-901, Brazil
e-mail: bioex.pucpr@gmail.com
Phone: (+55 48) 32716333