Lab overview

Bioex is linked to the Graduate Program in Health Sciences (PPGCS) of the School of Medicine at the Pontifical Catholic University of Paraná (PUCPR) in Brazil. Our research aims to understand the biochemical and molecular mechanisms induced by physical exercise on the redox biology in diverse tissues and organs. We use advanced technologies and research techniques to explore and investigate the scientific hypotheses formulated in our Laboratory. Our research is supported by government funding and other foundations.


The Bioex team is composed of researchers, undergraduate and postgraduate students (master's and doctorate), post-doc and collaborators. Know more about the members of our team below.

Metal escovado
IMG_2075 - Copia.JPG

Head of Lab and main investigator

Ricardo A. Pinho, PhD

Dr. Pinho has an undergraduate and a Master's degree in Physical Education (UFSC, Brazil,1992/1999) and a Ph.D. in Biological Sciences - Biochemistry (UFRGS, Brazil, 2005). Senior postdoctorate at the Muscle Health Research Centre - YU - Toronto. Dr. Pinho was the Director of Community Affairs, Coordinator for Graduate Studies and Research in Health Science, and Pro-rector for Graduate Studies and Research at Universidade do Extremo Sul Catarinense. Currently, Dr. Pinho is a professor of Graduate and undergraduate programs at the School of Medicine at Pontificia Universidade Católica do Paraná (PUCPR), Brazil. In the Graduate Program in Health Sciences, Dr. Pinho is a professor and supervisor (MSc and Ph.D.) and Head of the Biochemistry of Exercise Lab in Health. He is a member of the Society for Free Radical Research - Europe and a Member of the Advisory Board in the Area of Biological Sciences of the Araucária Foundation (Paraná, Brazil). Acts as a reviewer for several international journals and is Associate Editor of The Annals of the Brazilian Academy of Science. Dr. Pinho has experience in the Biochemistry and physiology of exercise, mainly oxidative stress and pathophysiology of chronic degenerative diseases. (CNPQ scientist , index-h = 34 ISI, 33 Scopus, 46 Google Scholar).




Our projects aim to investigate the role of physical exercise and antioxidants on the redox response of degenerative diseases. Research in the  BIOEX involves a constant review of the scientific issues on exercise and health.The strength of our research lies in the breadth and depth of the experimental approaches we use in understanding the molecular and biochemical mechanisms induced by physical exercise. Learn more about our current research projects below.

Metal escovado

Regulation of resistance physical exercise on oxidative stress parameters and genetic variations in different stages of sarcopenia

Resistance Exercise Modulates Oxidative Stress Parameters and TNF-α Content in the Heart of Mice with Diet-Induced Obesity.

Effects of chronic treatment with gold nanoparticles on inflammatory responses and oxidative stress in Mdx mice.

Cardioprotective effects of physical exercise on redox biology in mice exposed to hand-rolled cornhusk cigarette smoke.

Swimming training improves mental health parameters, cognition and motor coordination in children with Attention Deficit Hyperactivity Disorder.

Effects of aquatic exercise on mental health, functional autonomy and oxidative stress in depressed elderly individuals: A randomized clinical trial.

Improvement in muscular strength and aerobic capacities in elderly people occurs independently of physical training type or exercise model.

Effects of photobiomodulation on mitochondria of brain, muscle, and C6 astroglioma cells.

Therapeutic effects of iontophoresis with gold nanoparticles in the repair of traumatic muscle injury.

Effects Of Treatment With Gold Nanoparticles In A Model Of Acute Pulmonary Inflammation Induced By Lipopolysaccharide.

Cardio-respiratory health effects of exposure to traffic-related air pollutants while exercising outdoors: A systematic review.

Effects of chronic treatment with gold nanoparticles on inflammatory responses and oxidative stress in Mdx mice.

Effects of Resistance Exercise on Cerebral Redox Regulation and Cognition: An Interplay Between Muscle and Brain


The results of our research are published in different international journals, which have been cited and recognized by other researchers. See some of our recent publications (2019/2021). You can find a complete list of our publications at

Exercise, redox system and neurodegenerative diseases

Biochim Biophys Acta Mol Basis Dis. 2020:165778

Yerba mate (Ilex paraguariensis St. Hil.) extract inhibits hand-rolled cornhusk cigarette smoke-induced oxidative pulmonary damage

An Acad Bras Cienc. 2020;92:e20191141

Susceptibility of the patients infected with Sars-Cov2 to oxidative stress and possible interplay with severity of the disease

Free Radic Biol Med. 2021 Mar;165:184-190.

Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model

An Acad Bras Cienc. 2021 May 31;93(2):e20191450.

Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model

An Acad Bras Cienc. 2021 May 31;93(2):e20191450.


Lab Symposium

Symposium of Exercise Biochemistry in Health


The Symposium of Exercise Biochemistry in Health is an event promoted by Bioex to disseminate scientific advances related to physical exercise's biochemical and molecular effects on human health. The event is held annually at PUCPR and has the participation of important researchers. In 2021 the event was held online on the 23rd, 24th, and 25th of June. 


A little of our scientific and social routine

©2019 by Laboratory of Exercise Biochemistry in Health. Proudly created with

Contact us

Thank you for your interest in our research. Please contact us if you have any questions or comments about our work and publications, or, if you wish to try out for a master´s degree, doctorate or a post-doc position. We would love to hear from you.

Adress: R. Imac. Conceição, 1155 - Prado Velho, Curitiba - PR, 80215-901, Brazil

Phone: (+55 48) 32716333

Suas informações foram enviadas com sucesso!